| Molecular Formula | C10H8N2O3 |
| Molar Mass | 204.18 |
| Density | 1.482±0.06 g/cm3(Predicted) |
| Melting Point | 247 °C |
| Boling Point | 544.4±50.0 °C(Predicted) |
| Appearance | Brown solid. |
| pKa | 8.81±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| In vitro study | (E)-AG 99 effectively blocks tyrosine phosphorylation of p145 met and promotes cell death accompanied by activation of caspase-like proteases. |
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.898 ml | 24.488 ml | 48.976 ml |
| 5 mM | 0.98 ml | 4.898 ml | 9.795 ml |
| 10 mM | 0.49 ml | 2.449 ml | 4.898 ml |
| 5 mM | 0.098 ml | 0.49 ml | 0.98 ml |
| use | tyrosine phosphorylation inhibitor A46 is mainly used as a pharmaceutical inhibitor. |
| biological activity | AG99 (Tyrphostin 46,Tyrphostin A46,Tyrphostin B40) is an effective and selective EGFR inhibitor. |
| target | TargetValue EGFR () |
| Target | Value |
| in vitro study | (E)-AG 99 effectively blocks tyrosine phosphorylation of p145 met and promotes cell death accompanied by activation of caspase-like proteases. |